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If we compare a cell to a bustling city, solute carrier (SLC) transport proteins are like the "logistics hubs" scattered throughout the city. They determine which nutrients can enter the city, which metabolic wastes must be transported away, and even directly participate in the city's "security" and

How are you doing with this recent flu wave? During the flu season, the teasing on wechat Moments came one after another: "You got vaccinated, why did you 

Why cAMP? In the field of life sciences, there is a molecule widely regarded as the “gold standard” of signal transduction research—cyclic adenosine monophosphate (cAMP). Since its Nobel Prize–level discovery in 1957, this tiny “second messenger,” composed o

Over half of the global population meets the diagnostic criteria for at least one psychiatric disorder in their lifetime, and "comorbidity" (having multiple disorders simultaneously) is common. Does the traditional diagnostic boundary still hold? A recent study in Nature shows, for the fir

Title：SENP6 Restrains NLRP3 Inflammasome Activation via DeSUMOylation-Driven K48-Linked Ubiquitination of NLRP3 in Acute Lung Injury Levels of IL-1β, IL-18, and TNF-α in the supernatants of peritoneal macrophages from SENP6^fl/fl and SENP6^fl/fl Lyz2-Cre mice following LPS priming

In ELISA experiments, the sufficient lysis of tissue samples and protein extraction are crucial steps determining the success of the experiment. Today, we will share the detailed operating conditions and precautions for several mainstream lysis methods.   Liquid Nitrogen Grinding Method