Catalog Number：RA20252
KV1.5 Rabbit Polyclonal Antibody(A257)
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Size：
50 μL
100 μL
Price：
$149.00
$249.00
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| Product Name | KV1.5 Rabbit Polyclonal Antibody(A257) | Species | H |
| Applications | WB | ||
| Condition | 1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. | ||
| Alternative Names | KCNA5,PCN5,Potassium channel 1,voltage gated potassium channel protein kv1.5 | ||
| Store | Store at -20°C. Stable for one year from the date of shipment. | ||
| Recommended dilutions | WB 1:1,000-2,000 | ||
| Specificity | Antibody can detect endogenous KV1.5 proteins. | ||
| Background | KV1.5 is a mammalianA voltage dependent K+A channel, homologous to theDrosophilaA ShakerA K+A channel. KV1.5 was first cloned from rat brain.A EightShakerA related genes exist in mammals constituting the KV1, subfamily of the large KVA channel family of genes.A functional KV1 channel is either a membrane spanning homotetramer or heterotetramer, which is composed of members of the same subfamily. In addition several auxiliary subunits and intracellular proteins might interact with the channel and affect its function.The structure of KV1.5 channel is similar to all KV channels and includes six membrane spanning helixes creating a voltage sensor domain and a pore domain. The channel is expressed in cardiac and smooth muscle tissue (colon, aorta, stomach and pulmonary artery) as well as in neurons and kidney.A loss of function mutation in the gene encoding the channel was found in atrial fibrilation patients, stressing its role as a cardiac action potential regulator.The functional channel is considered transient (A-type) channel and shows prominent inactivation. Therefore, this channel activity influences the membrane potential and excitability of neurons and muscle.KV1.5 channels are sensitive to high doses of TEA (330 mM) and low doses of 4-AP (0.27 mM) | ||
| Molecular Weight | 67KD | Isotype | IgG |
| GeneID | 3741 | Protein MW | 67KD |
| SWISS | P22460 | Source | Rabbit |
| Antigen | Synthetic Peptide | Category | Polyclonal |
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Western blot analysis of 293T with KV1.5 Rabbit pAb diluted at 1:2,000.