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What are the common cytokines？

Cytokines can be classified into several categories, including growth factors, chemokines, apoptotic factors, mediators of inflammation, and so on. Common cytokines include interleukin, tumor necrosis factor, interferon, chemokines and so on.

 

What diseases are cytokines associated with?

Changes in cytokines are associated with a variety of diseases, and the following common disease models are associated with them:

• Inflammatory disease: Cytokines play an important role in the inflammatory response. Excessive or abnormal inflammatory response is associated with a variety of inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel diseases (such as Crohn's disease and ulcerative colitis), psoriasis, and so on. In these diseases, abnormal production and regulation of cytokines, such as TNF-α, IL-1β, IL-6, etc., lead to excessive activation of immune cells and excessive release of inflammatory mediators.

 

• Autoimmunity disease: Autoimmune diseases are diseases in which the immune system mistakenly attacks its own tissues and organs. A variety of autoimmune diseases are related to abnormal production and function of cytokines, such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis and so on. Excessive production or abnormal regulation of certain cytokines, such as IL-2, IL-4, IL-10, IL-12, IL-17A, TNF-α, TGF-β1 and IFN-γ, can trigger autoimmune responses, leading to inflammation and tissue damage. Details are as follow:

Systemic lupus Erythematosus: IL-6, IL-10, IFN-γ and other cytokines are associated with inflammatory response, autoantibody production and organ damage.

Rheumatoid arthritis: TNF-α, IL-1β, IL-6 and other cytokines are involved in the process of synovial inflammation and joint destruction.

Multiple Sclerosis: IL-2、IL-4、IL-10、IFN-γ and other cytokines are associated with autoimmune responses and nerve damage.

 

• Tumor: Cytokines play an important role in the occurrence, growth and metastasis of tumors. Certain cytokines can promote tumor cell proliferation, angiogenesis, and infiltration, and inhibit tumor recognition and clearance by the immune system. Such as TNF-α, IL-1β, IL-6, IL-8, TGF-β1, GM-CSF and IFN-γ are closely related to the development and prognosis of tumors. Details are as follow:

 

• Infectious disease: In the process of infection, cytokines are involved in the regulation of immune response and inflammatory response to combat pathogen invasion. In some infectious diseases, such as severe infection and sepsis, excessive production of cytokines such as TNF-α, IL-1β and IL-6 can lead to systemic inflammatory response syndrome (SIRS) and organ failure.

About cytokines, what are our ELISA kit products?

Reed Biotech® adhering to the customer demand as the key to the market concept, based on the conventional ELISA kit, Micro Fast (MF) series has been developed, and the high-sensitivity series of ELISA kit products have been developed to meet the needs of customers. The following is the corresponding product information of the above indicators:

Catalog Number	Testg Target	Species	Application
RE3186HF	Human IL-6	Human	ELISA
RE1060MF	Mouse TNF-α	Mouse	ELISA
RE1026MF	Mouse GROα/CXCL1	Mouse	ELISA
RE1059MF	Mouse IFN-γ	Mouse	ELISA
RE2862HF	Human GM-CSF	Human	ELISA
RE10013F	TGF-β1	Universal	ELISA
RE2867MF	Mouse IL-17A	Mouse	ELISA
RE1055HF	Human IL-4	Human	ELISA
RE2866RF	Rat IL-2	Rat	ELISA
RE1060HF	Human TNF-α	Human	ELISA
RE1059HF	Human IFN-γ	Human	ELISA
RE1059RF	Rat IFN-γ	Rat	ELISA
RE1055HG	Human IL-4	Human	ELISA