Catalog Number：RA10252
Claudin-2 Mouse Monoclonal Antibody（8H11）
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Size：
50 μL
100 μL
Price：
$198.00
$298.00
Delivery： Order now, ship in 3 days
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| Product Name | Claudin-2 Mouse Monoclonal Antibody（8H11） | Species | H, R, M |
| Applications | WB,IHC | ||
| Condition | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. | ||
| Alternative Names | Claudin2,CLDN2,SP82 | ||
| Store | -20°C. Do not aliquot the antibody. | ||
| Recommended dilutions | WB: 1:1,000~2,000 IHC：1:100~200 Optimal dilutions should be determined by the end user. | ||
| Specificity | Claudin-2 antibody detects endogenous Claudin-2 proteins. | ||
| Background | The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney, where it regulates transepithelial ion (e.g., Na+, Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines , including A549 lung adenocarcinoma cells, where its nuclear distribution was positively associated with enhanced proliferation . | ||
| Molecular Weight | 25KD | Isotype | IgG1 |
| GeneID | 9075 | Protein MW | 25 |
| SWISS | P57739 | Source | Mouse |
| Antigen | Synthetic Peptide | Category | Monoclonal |
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Western blot analysis of 1) Hela Cell Lysate, 2) Mouse Heart Tissue Lysate , 3) Rat Heart Tissue Lysate using Claudin-2 Mouse mAb diluted at 1:2000.
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Immunohistochemical analysis of paraffin-embedded Human Kidney Carcinoma Tissue using Claudin-2 Mouse mAb diluted at 1:200.