Catalog Number：RA10398
Cleaved PARP Mouse Monoclonal Antibody(M4)
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Size：
50 μL
100 μL
Price：
$198.00
$298.00
Delivery： Order now, ship in 3 days
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| Product Name | Cleaved PARP Mouse Monoclonal Antibody(M4) | Species | H |
| Applications | WB, IHC | ||
| Condition | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. | ||
| Alternative Names | PARP-1, Poly(ADP ribose) polymerase 1, sPARP1,ADPRT1, ADP ribosyltransferase NAD(+) | ||
| Store | -20°C. Do not aliquot the antibody. | ||
| Recommended dilutions | WB: 1:1,000-3,000 IHC: 1:200-500 Optimal dilutions should be determined by the end user. | ||
| Specificity | Antibody can detects endogenous pro and active PARP protein. | ||
| Background | Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate. | ||
| Molecular Weight | 116KD(Pro) 89(Active) | Isotype | IgG1 |
| GeneID | 142 | Protein MW | 116,89 |
| SWISS | P09874 | Source | Mouse |
| Antigen | Synthetic Peptide | Category | Monoclonal |
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Western blot analysis of 1) Jurkat ,2) Hela, with Cleaved PARP Mouse mAb diluted at 1:2,000.
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Immunohistochemical analysis of paraffin-embedded human Tonsil Tissue using Cleaved PARP Mouse mAb diluted at 1:500.