Catalog Number：RA10167
PDGFRα Mouse Monoclonal Antibody(4G11)
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Size：
50 μL
100 μL
Price：
$198.00
$298.00
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| Product Name | PDGFRα Mouse Monoclonal Antibody(4G11) | Species | H,R,M |
| Applications | IHC | ||
| Condition | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. | ||
| Alternative Names | |||
| Store | -20°C. Do not aliquot the antibody. | ||
| Recommended dilutions | IHC: 1:100-200 Optimal dilutions should be determined by the end user. | ||
| Specificity | The antibody can detects endogenous PDGFRα proteins. | ||
| Background | Platelet derived growth factor (PDGF) family proteins exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC, and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). PDGFRα and PDGFRβ can each form heterodimers with EGFR, which is also activated by PDGF. Various cells differ in the total number of receptors present and in the receptor subunit composition, which may account for responsive differences among cell types to PDGF binding. Ligand binding induces receptor dimerization and autophosphorylation, followed by binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules, such as GRB2, Src, GAP, PI3 kinase, PLCγ, and NCK. A number of different signaling pathways are initiated by activated PDGF receptors and lead to control of cell growth, actin reorganization, migration, and differentiation. | ||
| Molecular Weight | ~180KD | Isotype | IgG1 |
| GeneID | 5156 | Protein MW | 180 |
| SWISS | P16234 | Source | Mouse |
| Antigen | Synthetic Peptide | Category | Monoclonal |
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Immunohistochemical analysis of paraffin-embedded Rat Skin Tissue using PDGFR a Mouse mAb diluted at 1:200.
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Immunohistochemical analysis of paraffin-embedded Human Skin Tissue using PDGFR a Mouse mAb diluted at 1:200.